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TREATMENT OF AIRWAY CONDITIONS BY MODULATION OF MIR200 FAMILY MICRORNAS
TREATMENT OF AIRWAY CONDITIONS BY MODULATION OF MIR200 FAMILY MICRORNAS
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机译:通过调制MiR200系列MicroRNA治疗气道条件
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摘要
The inventions provide the art with novel treatments of various airway conditions such as asthma wherein pathological production of mucus is implicated. Disclosed are novel inhibitors of miR-200 micro-RNAs, including inhibitors of miR-141. These miRNAs promote pathological mucus production and other airway dysfunction. They may be targeted by antagomirs which disrupt their activity. Additionally, they may be targeted by compositions with disrupt the gene expression of the targeted miR.
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