GASTRIC HYDROCHLORIC ACID SECRETION INHIBITOR, PROCESS FOR THE MANUFACTURE OF SUCH COMPOUNDS, PHARMACEUTICAL COMPOSITION AND A METHOD FOR THE INHIBITION OF GASTRIC HYDROCHLORIC ACID SECRETION

摘要

A process for the preparation of a pharmaceutical composition based on carbamic acid derivatives, with a greater inhibitory effect on the activity of reducing gastric hydrochloric acid secretion of anticholinergically active substances, characterized by adding to said anticholinergic substance at least one compound of the formula **(See formula)** wherein R1 is selected from the group consisting of straight and branched alcohol and alkenyl containing from 1 to 6 carbon atoms, cycloalkyl and cycloalkenyl groups containing not more than 6 carbon atoms, straight and branched alkoxyalkyl groups containing from 2 to 8 carbon atoms, and the radical **(See formula)** wherein A represents a bivalent radical selected from the group consisting of straight and branched alcoholic groups containing 1 to 4 carbon atoms, straight and branched alcoholoxy groups containing 1 to 4 carbon atoms and attached to the phenyl nucleus through the oxygen atom, and straight and branched alcoholylene-xyalkylene groups containing from 2 to 8 carbon atoms and are attached to the phenyl nucleus through one carbon atom, and R4 and R5 are the same or different and are selected from the group consisting of hydrogen, hydroxyl, alcohol and alkenyl groups containing 1 to 5 carbon atoms, including isopropyl, alkoxy and alkenoxy groups containing 1 to 3 carbon atoms, including isopropoxy, straight and branched hydroxyalkyl groups containing from 1 to 4 carbon, fluorine, chlorine, bromine, nitro, formyl and amino atoms; and R2 is selected from the group consisting of hydrogen, straight and branched alcohol and alkenyl groups containing from 1 to 4 carbon atoms, cycloalkyl and cycloalkenyl groups containing a maximum of 6 carbon atoms, straight and branched alkoxyalkyl groups containing from 2 to 8 carbon atoms, straight and branched alkoxyalkoxyalkyl groups containing 3 to 9 carbon atoms, and the radical -CO-R3, in which R3 is selected from the group consisting of straight and branched alkenyl alcohol groups containing 1 to 4 carbon atoms, straight and branched alkoxy and alkenoxy groups containing 1 to 4 carbon atoms, straight and branched alkoxyalkoxy groups containing 2 to 8 carbon atoms, straight and branched alkoxyalkoxyalkoxy groups containing 3 to 9 atoms carbon, straight and branched alkoxyalkyl groups containing 2 to 8 carbon atoms, and the radical **(See formula)** wherein R4 and R5 are as defined above, and B represents a valence line or a bivalent radical selected from the group consisting of alkoxy groups containing 1 to 4 carbon atoms and unique to the phenyl nucleus through of a carbon atom, and by transforming the mixture into an orally administrable dosage unit. (Machine-translation by Google Translate, not legally binding)