PROCESS FOR THE PREPARATION OF 15-HYDROXY-15-ALKENYL-9/OXO-PROSTA-(5Z-13E)DIENOIC ACID DERIVATIVES AND CERTAIN PRODUCTS OBTAINED BY SAID PROCESS

摘要

1478262 Prostaglandins ROUSSEL UCLAF 23 June 1975 [21 June 1974] 26591/75 Heading C2C The invention comprises a process for the preparation of prostaglandins of the Formula I wherein R is H or C 1-4 alkyl, R 1 is C 2-4 alkenyl which contains a group of the formula m is 3, 4 or 5 and n is 2, 3 or 4, by catalytically hydrogenating compounds of the above Formula I in which R 1 is C 2-4 alkynyl and the compounds methyl (5Z, 8RS, 12RS, 13E, 15SR) 15- hydroxy - 9 - oxo - 15 - vinyl - 5,13 - prostadienoate and methyl (5Z 8RS, 12RS, 13E, 15RS) 15 - hydroxy - 9 - oxo - 15 - vinyl - 5,13- prostadienoate. Pharmaceutical compositions, suitable for oral, parenteral, rectal or topical administration, contain the above named compounds together with pharmaceutical carriers or excipients. The compounds have hypotensive and anti-broncho-constrictive activities and stimulate contraction of the smooth muscles.