Processing Technology of Mongolian Artemisia frigida Willd. and Pharmacological Study on Processed Products

摘要

[Objectives] To optimize the processing technology of Mongolian Artemisia frigida Willd. and observe the safety and effectiveness of processed products. [Methods] The orthogonal test was conducted with the content of chlorogenic acid( CGA) in processed products and quercetin as the main indicator and reference factors. The impact of frying temperature and time and medicinal material granularity were examined to determine the optimal process. The safety and effectiveness were evaluated through adopting acute toxicity test in mice,and the bleeding time was determined by tail docking experiments,the blood coagulation time was determined with orbital venous plexus,the total number of platelets was counted for the whole blood. [Results]When the product was flipped and fried at the temperature of 270 ℃ for 20 min,the best effect was achieved. From the variance analysis,it proved that the frying temperature and the time and granularity had no significant effect on the content of the two components monitored. After processing,Artemisia frigida Willd.,it can shorten the bleeding time of mice and significantly increase the platelet number. [Conclusions]Appropriate frying can improve the safety and hemostatic effect. Therefore,this study can provide reference for verifying the theory of use of traditional Mongolian Artemisia frigida Willd.