ANALOGIFREMGANGSMAADE PRODUCING 17ALFA-ACYLOXY-9ALFA,21-DIHALOGEN-11BETA-HYDROXY-6ALFA-FLUOR-16ALFA-METHYL-PREGNA-1,4-DIEN-3,20-DION-FORBINDELSER

摘要

Novel 6 alpha ,9 alpha ,21-trihalogeno-11 beta -hydroxy-16 alpha or 16 beta -methyl-17 alpha -propionyloxy-pregn-4-ene-3,20-dione compounds of the formula IMAGE (I) in which X represents chlorine or flourine, R represents the group -CH2CH-, -CH=CH- or -CH=CCl-, the chlorine atom being in the positon 2 of the steroid numbering, and in which the 16-methyl radical is alpha - or beta -oriented, are useful pharmaceuticals, especially anti-inflammatory agents for topical administration.