PREPARATION OF 9-(BETA-D-ARABINOFURANOSYL)ADENINE

摘要

PURPOSE:To obtain the titled compound useful as an antiviral agent, etc. industrially advantageously, treating a specific siloxane-containing adenosine with dimethyl sulfoxide and acetic anhydride, reducing the reaction product, circulating a starting substance prepared as a by-product, eliminating a protecting group from the reduction product. CONSTITUTION:A 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)adenosine shown by the formula I (R is isopropyl group) is treated with dimethyl sulfoxide and acetic anhydride to give a corresponding 2'-keto derivative shown by the formula II. This substance is reduced, 9-[3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-beta-D-arabinofuranosyl ]adenosine shown by the formula III and the starting substance are separated from the reaction mixture, the latter is circulated through the first process, the protecting group is eliminated from the reduction product shown by the formula III, to give the desired compound shown by the formula IV.