5-FLUOROURACIL DERIVATIVE, INHIBITOR OF BLOOD PLATELET AGGREGATION USING IT, AND PREVENTIVE FOR CANCER METASTASIS USING IT

摘要

NEW MATERIAL:A 5-fluorouracil derivative shown by the formula (R is acyl group derived from higher fatty acid of hexaene). EXAMPLE:1-(4,7,10,13,16,19-decosahexenoyl)-5-fluorouracil. USE:An inhibitor of blood platelet aggregation, preventive for cancer metastasis, or carcinostatic agent. A dose is 0.1-5g/adult/day, being administered orally, or by venoclysis or by hypodermic injection optionally 1-3 times, dividedly. PREPARATION:For example, a higher fatty acid of hexaene, preferably higher fatty acid having 22-24C is reacted with 5-fluorouracil in the presence of a condensation agent such as 2-chloro-1-methylpyridinium p-toluenesulfonate, etc. to give a compound shown by the formula.