Platelet aggregation inhibitors using novel peptides and electropeptides, blood coagulation inhibitors of blood circulating in vitro, cell adhesion inhibitors, tumor metastasis inhibitors, protectants for blood platelet preparations for transfusion, platelet preparations for blood transfusion and platelet preparation packs

摘要

The present invention provides a peptide represented by the following general formula (I) or a salt thereof:;P-Ser-A-B-Asp-C-D (I);Wherein A is an amino acid having no guanidino group in the side chain, B is an amino acid, C is an amino acid having a hydrophobic group in the side chain, and D is a hydroxyl group or an amino group .;The peptide or its salt of the present invention is useful because it exhibits excellent platelet aggregation inhibiting ability and blood coagulation inhibiting ability and is very safe for living body.;In addition, the present invention provides the following drugs comprising an electro peptide or a salt thereof as an active ingredient: a platelet aggregation inhibitor; Blood coagulation inhibitors; Tumor metastasis inhibitors; And a prophylactic agent for platelet preparations. The present invention also relates to a pharmaceutical preparation comprising an electropeptide or a salt thereof, and a pharmaceutically acceptable carrier; A method of inhibiting platelet aggregation comprising administering to a patient an effective amount of a pharmaceutically acceptable carrier and an electro peptide or a salt thereof; A method of inhibiting blood coagulation of extracorporeally circulating blood, comprising the step of administering to a patient an effective amount of an electropeptide or a salt thereof together with a pharmaceutically acceptable carrier; A method of inhibiting cell adhesion comprising administering to a patient an effective amount of an electropeptide or a salt thereof together with a pharmaceutically acceptable carrier; A method of inhibiting tumor metastasis, comprising administering to a patient an effective amount of an electropeptide or a salt thereof together with a pharmaceutically acceptable carrier; And a step of adding an effective amount of an electro peptide or a salt thereof to the platelet agent, to thereby protect the platelets contained in the platelet agent for transfusion.