Hexapeptides with vasodilating and hypotensive activity are described corresponding to the formula: IMAGE (I) wherein: X is a hydrogen atom or an acyl radical R3-CO- wherein R3 is a straight or branched (C1-C7)alkyl group, R1 and R2, each independently, represent the side-chain residue of the amino acid glycine (-H), alanine (-CH3), valine IMAGE leucine IMAGE or isoleucine IMAGE Arg is the abbreviated designation for arginine, Pro is the abbreviated designation for proline, Tyr is the abbreviated designation for tyrosine, and the pharmaceutically acceptable salts, lower alkyl esters and amides thereof, a process for their preparation and the pharmaceutical compositions containing them.
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机译：描述具有以下各项的具有血管舒张和降压活性的六肽：（I）其中：X是氢原子或酰基R3-CO-，其中R3是直链或支链（C1-C7）烷基，R1 R 1和R 2各自独立地表示氨基酸甘氨酸（-H），丙氨酸（-CH3），缬氨酸亮氨酸或异亮氨酸的侧链残基。Arg是精氨酸的缩写，Pro脯氨酸是脯氨酸的缩写名称，酪氨酸是酪氨酸及其药学上可接受的盐，低级烷基酯和酰胺的缩写名称，其制备方法和包含它们的药物组合物。
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