PROCESS FOR PREPARING SUBSTITUTED 3,4-DIAMINO-1,2,PROCESS FOR THE PREPARATION OF 3,4-DIAMINO-1,2,5-TIADIAZOLES SUBSTITUTED WITH ANTI-HISTAMINIC ACTIVI5-THIADIAZOLES HAVING HISTAMINE H2-RECEPTOR ANTAGOTY NIST ACTIVITY

摘要

Histamine H2-receptor antagonists of the formula IMAGE wherein A, m, Z, n and R1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula IMAGE