Amino-purine derivs. of formula (I) in which R is H or NH2 are made by (a) treating 2-amino purine opt. substd. in position 6 and provided with an amino gp. with a protective agent for amino gps. (hexamethyl disilazane) at 50-125 deg. C in an inert atmos. (b) alkylating the prod. with a chlorinated deriv. (II) in which Y is 1-4C alkyl, in anhydrous toluene or benzene, in presence of a tert. amine and at 40-110 deg. C; (c) treating the prod. with an aq. alcohol e.g. ethanol or propanol to remove the protective gps., and (d) reacting with ammoniaor a prim. amine to break the ester gps. in 9-position and obtain (I).
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