Sulphonated chiral phosphines, their preparation and their use in asymmetric catalysis

摘要

The invention provides novel sulphonated chiral phosphines of the formula: IMAGE in which R represents an alkyl radical, a cycloalkyl radical optionally substituted with an alkyl radical, a cycloalkylalkyl radical optionally substituted with an alkyl radical, a phenyl, phenylalkyl, binaphthyl or binaphthylalkyl radical, in which the alkyl, cycloalkyl, phenyl and binaphthyl radicals, and the alkyl portions of the other radicals, can be substituted by a radical of general formula: IMAGE R1 represents an alkyl, cycloalkyl, phenyl, or phenylalkyl radical, Ar represents a phenyl or naphthyl radical, m+ represents a proton or alkali metal ion or alkaline earth metal ion, m=1 or 2, n=0, 1 or 2, p=1 or 2, (p+m) /=3, and R and R1 can be chiral or achiral. These chiral phosphines form water-soluble metal complexes useful as catalysts in asymmetric organic synthesis.