NOVEL TETRACYCLIC ALKALOID FK SEPARATED FROM COCCULUS TRILOBUS BELONGING TO MENISPERMACEAE FAMILY AND PRODUCTION THEREOF

摘要

NEW MATERIAL:The tetracyclic alkaloid FK 1000 of formula. USE:A carcinostatic agent. PREPARATION:Small chips of the root of a plant belonging to Cocculus trilobus harvested in autumn are extracted with methanol, etc., and a water-transferable fraction of the extract is treated with a spherical resin of a porous polymer such as Amberlite XAD-2. A fraction separated by using water as mobile phase is purified by silica gel column chromatography to obtain the objective substance.