Process for the production of an amide derivative, compound of 4 - chloro - N - (1 - cyano - 1 - ethoxy) methyl - benzamida and compound 4 - bromine - N - (1 - cyano - 1 - methyl - benzamida ethoxy)

摘要

A process for the production of a substituted amide of the formula: CHEM where R1 is an optionally substituted aryl group, X1 is -O-or -S- and R2 is an optionally substituted alkyl, alkenyl, or alkynyl group or X1R2 is an N-linked 5-membered nitrogen heterocycle comprising the halogenation, preferably bromination, in an inert solvent of an N-cyanomethyl-amide of the formula R1CONH.CH2CN, followed by addition to the halogenated mixture, or to the mixture as halogenation is taking place, of a heterocyclic tertiary amine in a proportion of from about 1.0 to about 2.5 moles for each mole of halogen reacted, and finally treatment of the resulting quaternary salt with an alcohol, thiol or amine of the formula R2X1H.