Analogifremgangsmaade for the preparation of 3-substituted pyrrolidines or piperidines and 3-substituted pyrrolidines or piperidines for use as starting material in the process

摘要

Compounds of the formula CHEM wherein Z3 is R or R6CO, wherein R is an alkyl group having 1-5 carbon atoms, a hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group having 2-6 carbon atoms in the alkyl part and having the heteroatom bound in a position other than 1-position, an alkenyl group having 3-5 carbon atoms other than an 1-alkenyl group, and R6 is an alkyl or alkoxy group containing 1-4 carbon atoms or an alkenyl group with 2-4 carbon atoms, R7 is an alkyl group with 1-5 carbon atoms, an allyl or benzyl group, and n is 1 or 2 provided that Z3 is other than methyl and ethyl when n is 2 and R7 is CH3 or an acid addition salt thereof. The compounds are useful as intermediates or starting materials for preparation of therapeutically useful substituted phenyl-azacycloalkanes.