33SUBSTITUTEDD66SUBSTITUTEDD77OXOO11 AZABICYCLO*3*2*0**HEPTAA22ENEE22CARBOXYLIC ACID

摘要

Disclosed are 3- and 6-substituted 7-oxo-1- aza-bicyclo [3.2.0] hept-2- ene-2- carboxylic acids having the structure: CHEM wherein R6, R7 and R8 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.