Process for the preparation of a compound compound r, s- (z) -alpha- (oximino-alpha- (1-azabicyclo) 2.2.2 -oct-3-yl) acetonitrile zwitterionic r- (z) - alpha- (oximino) -alpha- (1-azabicyclo) 2.2.2 -oct-3-yl) acetonitrile zwitterionic acid alpha -cyano-1-azabicyclo 2.2.2 -octane-3-acetic process for resolving r, s -alpha- (methoximino) -alpha- (1-azabicyclo) 2.2.2 -oct-3-yl) acetonitrile and process for the solution of r, s- (z) - alpha (oximino) - alpha (1-azabicycles 2.2.2 -oct-3-yl) acetonitrile and process for the preparation of r- (z) - alpha- (methoxyimino) -alpha- (1-azabicycles) 2.2.2 -oct-3-yl) acetonitrile

摘要

A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: IMAGE (I) wherein R1 represents IMAGE in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R2 is a group OR4, where R4 is C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl or a group OCOR5 where R5 is hydrogen or R4; and R3 is CN; said process comprising reacting a compound of formula (II): IMAGE (II) wherein R1' is R1 or a group convertible thereto, and R3' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting =NOH group to =NR2 wherein R2 is as defined in formula (I), converting R1' and R3' when other than R1 and R3 to R1 and R3, and thereafter optionally forming a pharmaceutically acceptable salt.