Compounds as described having the partial formula IMAGE These compounds may have a 5-OH or -OMe group amd at the 25- position an isopropylene group substituted by methyl, ethyl or isopropyl. The compounds may be used in agriculture or medicine as antiparasitics, and may be prepared by culturing certain Streptomyces strains, in particular Streptomyces thermoarchaensis NCIB 12015.
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