METHOD OF OBTAINING A PHARMACEUTIC, METHOD OF OBTAINING PREDETERMINED AMOUNT OF ANTIBODY FROM PHYSIOLOGIC SALINE, APPARATUS FOR SELECTIVELY ISOLATING A SPECIFIC PPOPULATION OF DESIRABLE ANTIBODY AND SET FOR ISOLATING SUCH ANTIBODY

摘要

PCT No. PCT/US90/05228 Sec. 371 Date Mar. 12, 1992 Sec. 102(e) Date Mar. 12, 1992 PCT Filed Sep. 14, 1990.The invention provides an apparatus and method for the preparation of a pharmaceutical composition comprising a complex of an antigen component and the corresponding antibody component in a pharmacologically acceptable carrier. The apparatus comprises a housing chamber for containing paramagnetic particles and a platform against which the housing chamber is releasably retained. The platform contains one or more magnets located adjacent to the housing chamber when the housing chamber is positioned on the platform. The platform is secured to a support which allows the platform, and thus the housing chamber, to be rotated between a vertical and a horizontal position. The method involves supplying a quantity of paramagnetic particles bearing the antigen component to the housing chamber, introducing into the housing chamber a physiological fluid which contains the antibody component, mixing the paramagnetic particles and the physiological fluid to form an antigen component and antibody component complex on the paramagnetic beads, removing the physiological fluid from the housing chamber, and eluting the antigen component and antibody component complex from the paramagnetic beads in a pharmaceutically acceptable eluting solution.