The separation of the human β subunit of the high affinity receptor for immunoglobulin E, characterization and usage

摘要

The present invention relates to nucleic acid sequences, encoding amino acid sequences of the alpha, beta, and gamma subunits of the high affinity receptor for immunoglobulin E, and for amino acid sequences of the subunits. The invention further relates to a method of producing the receptor by expressing cDNA for its alpha, beta, and gamma subunits in a host cell simultaneously. Aspects of the invention are methods and compositions to inhibit the function of the human beta subunit, thereby treating or preventing allergic reactions.