ISOLATION, CHARACTERIZATION, AND USE OF THE HUMAN .BETA. SUBUNIT OF THE HIGH AFFINITY RECEPTOR FOR IMMUNOGLOBULIN E

摘要

The present invention relates to nucleic acid sequences encoding amino acidsequences of the .alpha., .beta., and .gamma. subunits of thehigh affinity receptor for immunoglobulin E, and for amino acid sequences ofthe subunits. The invention further relates to amethod of producing the receptor by expressing cDNA for its .alpha., .beta.,and .gamma. subunits in a host cell simultaneously. Aspects of theinvention are methods and compositions to produce the human beta subunit, aswell as to inhibit its function, thereby treating orpreventing allergic reactions.