3-FLUORO-4-CHLORO-6-NITROBENZALDEHYDE, 3-FLUORO-4-CHLORO-6-NITROBENZALDEHYDE ACETAL AND THEIR PRODUCTION

摘要

PURPOSE: To obtain 3-fluoro-4-chloro-6-nitrobenzaldehyde and its acetal which can give a quinoline in high yield and is useful as a synthetic intermediate for an antiallergic. ;CONSTITUTION: 3-Fluoro-4-chloro-6-nitrobenzaldehyde of formula I. The compound of formula I is obtained by nitrating 3-fluoro-4-chloro-benzaldehyde with the mixed acid. 3-Fluoro-4-chloro-6-nitrobenzaldehyde acetal of formula II is prepared by reaction of 3,4-dichlor-6-nitrobenzaldehyde acetal with an alkali metal fluoride in a polar solvent or by reaction of the compound of formula I with an aliphatic alcohol or an ortho-acid trialkyl ester in the presence of an acid catalyst.;COPYRIGHT: (C)1996,JPO