Anti-inflammatory, tolerogenic and immunostimulatory properties of carbohydrate-binding proteins

摘要

The invention is directed to a lectin derived carbohydrate binding-peptide which inhibits cell-mediated immune responses and has the amino acid sequence SPYGRC. The peptide binds terminally linked alpha -sialic acid (2-3) beta Gal- and alpha -sialic (2-6) beta Gal-structures and is a acid fragment of the S2 subunit of pertussis toxin produced by Bordetella pertussis.