Pyrazolo (1,5-a) pyrimidine derivatives (PYRAZOLO 1,5-a PYRIMIDINE DERIVATIVE)

摘要

The present invention provides pyrazolo [1,5-a] pyrimidine derivatives of the general formula:;Wherein R ¹ is hydrogen, lower alkyl, cycloalkyl, thienyl, furyl, lower alkenyl, or lower alkyl, lower alkoxy, which may have thienyl, lower alkoxy, lower alkylthio, oxo or hydroxyl as substituents Phenyl which may have from 1 to 3 substituents selected from the group consisting of phenylthio and halogen; R ² is naphthyl, cycloalkyl, furyl, thienyl, optionally halogen-substituted pyridyl, optionally halogen-substituted phenoxy, or lower alkyl, lower alkoxy, halogen, nitro, halogen-substituted lower alkyl, 1 to 3 selected from halogen-substituted lower alkoxy, lower alkoxycarbonyl, hydroxyl, phenyl (lower) alkoxy, amino, cyano, lower alkanoyloxy, phenyl and di (lower) alkoxyphosphoryl (lower) alkyl Phenyl which may have a substituent; R ³ is hydrogen, phenyl or lower alkyl; R ⁴ is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl (lower) alkyl, optionally phenylthio-substituted phenyl, or halogen; R ⁵ is hydrogen or lower alkyl; R ⁶ is benzoyl having 1 to 3 substituents selected from the group consisting of hydrogen, lower alkyl, phenyl (lower) alkyl, or lower alkoxy, halogen-substituted lower alkyl and halogen; R ¹ and R ⁵ may together form a lower alkylene; Q is carbonyl or sulfonyl; A is a single bond, lower alkylene or lower alkenylene; n is 0 or 1;;Such derivatives are useful as analgesics.