PYRAZOLIDINE DERIVATIVE AND FREE RADICAL SCAVENGER AND ISCHEMIC REPERFUSION HINDARANCE INHIBITOR

摘要

PURPOSE: To obtain the subject new compound useful for brain edema, cerebral infarction, cardiac infarction, arrhythmia, etc., as a free radical scavenger, having antioxidant action and lipid peroxidation suppressing action and having high safety. ;CONSTITUTION: This pyrazolidine derivative is expressed by formula I [A is CH₂, CO or CH₂CO; B is O or NH; R₁ is H or a lower alkyl or a lower alkenyl; R₂ is a lower alkenyl, benzyl, pyridylmethyl, etc.; (n) is 1 or 2; R₃ and R₄ are each a lower alkyl, a lower alkenyl or benzyl], and its salt, e.g. 4-(2-benzyloxy-3- isobutylbenzyloxy)-1,2-diethylpyrazolidine. The compound of formula I is obtained from e.g. a carboxylic acid of formula II (A₁ is CO or H₂CO) and an amine of formula III.;COPYRIGHT: (C)1996,JPO