Effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction

摘要

Objective:To investigate the effects of Sofren injection combined with oxygen free radical scavenger on neural function and apoptosis in patients with acute cerebral infarction.Methods:The patients with acute cerebral infarction who received treatment in Xi'an Union Hospital between September 2016and February 2018 were selected as the study subjects and divided into the control group and Sofren injection group by random number table method. Control group received both conventional treatment and oxygen free radical scavenger treatment, and Sofren injection group received both conventional treatment and Sofren injection combined with oxygen free radical scavenger treatment. The differences in serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were compared between the two groups before treatment (T0), after 1 week of treatment (T1), and after 2 weeks treatment (T2).Results: At T0, serum levels of neurotrophy indexes, nerve injury indexes and neural apoptosis indexes were not significantly different between the two groups. At T1 and T2, serum neurotrophy indexes IGF-1, bFGF, BDNF and GDNF levels of Sofren injection group were higher than those of control group; serum nerve injury indexes RBP4, H-FABP, SAA and NPY levels were lower than those of control group; serum neural apoptosis index Bcl-2 level was higher than that of control group whereas Bax and caspase-3 levels were lower than those of control group.Conclusion: Sofren injection combined with oxygen free radical scavenger therapy can effectively optimize the neural function and inhibit the neural apoptosis in patients with acute cerebral infarction.