首页> 外国专利> COMPOUNDS, DERIVATIVES OF INDANE, METHOD OF THEIR OBTAINING AND INTERMEDIATE PRODUCTS OF THEIR OBTAINING, THEIR APPLICATION AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS, CONTAINING THEM

COMPOUNDS, DERIVATIVES OF INDANE, METHOD OF THEIR OBTAINING AND INTERMEDIATE PRODUCTS OF THEIR OBTAINING, THEIR APPLICATION AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS, CONTAINING THEM

机译:化合物,茚满衍生物,其获得方法及其中间产物,其作为药物产品和药物组合物的应用,包含它们

摘要

The invention relates to compounds of the formula in which r 1 and r 2, identical or different, represent a hydrogen atom or an alkyl radical containing from 1 to 5 carbon atoms or r 1 and r 2 together with the carbon atom to which they are attached form a cycloalkyl containing between 3 and 6 carbon atoms, and may optionally contain a heteroatom such as oxygen, sulfur or nitrogen; and R6 and R7, which may be the same or different, represent a halogen atom, an alkyl radical or an alkoxy group containing from 1 to 5 carbon atoms, and in that one is from the group of the formula wherein r represents a hydrogen atom or an alkyl group with 1 to 5 carbon atoms; z is a linear alkylene chain- (CH2) n; n is a number which can be changed from 0 to 5 or a branched alkylene chain having 2 to 8 carbon atoms or the group -Cn2 -O, x, x 'and x' ', the same or different, represent a hydrogen atom, an alkyl radical or alkoxy of 1 to 4 carbon atoms, halogen atom, hydroxyl radical, trifluoromethyl, nitro, amino, monoalkylyl dialkylamino or sulfoamino group, and the other of substituents a or b are selected from the group of formula wherein R3 and R4, identical or different, represent a hydrogen atom or an alkyl radical of 1 to 5 carbon atoms or r 3 and r 4 form a one to the nitrogen atom to which they are attached, a 5- or 6-membered heterocycle which optionally contains another heteroatom such as oxygen, nitrogen or sulfur, wherein the nitrogen atom is optionally substituted with an alkyl radical of 1 to 4 carbon atoms; and
机译:本发明涉及下式的化合物,其中r 1和r 2相同或不同,代表氢原子或含有1至5个碳原子的烷基或r 1和r 2连同它们所处的碳原子连接形成含有3至6个碳原子的环烷基,并且可以任选地包含杂原子,例如氧,硫或氮; R 6和R 7可以相同或不同,表示卤原子,烷基或含1至5个碳原子的烷氧基,其中一个来自下式的基团,其中r表示氢原子或具有1至5个碳原子的烷基;或z是线性亚烷基链-(CH 2)n; n为可从0至5变化的数字或具有2至8个碳原子的支链亚烷基链,或相同或不同的-Cn2-O,x,x'和x''基团表示氢原子,具有1-4个碳原子的烷基或烷氧基,卤素原子,羟基,三氟甲基,硝基,氨基,单烷基二烷基氨基或磺氨基,以及取代基a或b中的另一个选自下式的组:其中R3和R4为:相同或不同,表示一个氢原子或一个1至5个碳原子的烷基,或r 3和r 4与它们所连接的氮原子形成一个5或6元杂环,该杂环可任选包含另一个杂原子例如氧,氮或硫,其中氮原子任选地被1-4个碳原子的烷基取代;和

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