PROCESS FOR THE PREPARATION AND PURIFICATION OF HUMAN INTERLEUKIN-3 RECOMBINANT OF THEIR MUTEINS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Recombinantly produced IL-3 is purified in a series of steps, initially employing hydrophobic interaction, followed by ion-exchange chromatography and gel filtration. Furthermore methods are provided for improved production of recombinant hIL-3 either in glycosylated form from mammalian and yeast cells or in unglycosylated form from prokaryotes.