Use of natural cyclodextrins and their derivatives for the solubilization of platelet anti-aggregating agents from the family of ginkgolides

摘要

Solubilising a ginkgolide platelet-activating factor antagonist (I) in aq. media comprises combining (I) with a cyclodextrin of formula (II) to form a water-soluble clathrate: n = 6-8; R1 = OH or SR2, and R2 = a gp. derived from a mono- or oligosaccharide. Also claimed are clathrates as above.