Use of specific core material and layers to obtain stable to discolouration of omeprazole pharmaceutical formulations.

摘要

DESCRIBED THE USE OF A MATERIAL FOR CORES IN THE FORM OF SMALL FLAKES or tablets containing as active compound omeprazole WITH A REACTIVE alkaline compound or salt ALKALINE omeprazole optionally together with a reactive alkaline compound, AND ON THE MENTIONED MATERIAL NUCLEUS ONE OR MORE LAYERS INERTES comprising excipients tABLET which are soluble or rapidly disintegrating in water or polymeric compounds water soluble film formers, optionally containing a cushion of PH, alkaline compounds between the reagent NUCLEO ALCALINO and an outer layer, WHAT IS an enteric coating, to obtain a preparation of omeprazole oral dosage which will be stable to discolouration.