The cellular type unique gene importation which uses the retro-virus vector which includes the antibody - envelope fusion protein and the wild die envelope fusion protein

摘要

The present invention pertains to retroviral vector particles having target cell specificity which comprises a retroviral vector having a targeting peptide fused to the envelope protein of the retroviral vector to form a targeting envelope, wherein the targeting peptide replaces or disrupts the natural viral receptor binding site and the targeting peptide is the antigen binding site of an antibody, the receptor binding peptide of another virus, or is a peptide that specifically binds to a specific receptor of the target.