Have the 7 (4 aminomethyl 3 oxime) pyro lysine substitution product the new quinoline carboxylic acid derivative and its production manner

摘要

The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to a novel quinoline(naphthyridine)carboxylic acid derivative represented by the following formula (I), which has an 4-aminomethyl-3-oximepyrrolidine substituent on 7-position of the quinolone nucleus and shows a superior antibacterial activity in contrast to the known quinolone antibactrial agents having a weak activity against gram-positive bacterial strains and also has a broad antibacterial spectrum and a highly improved pharmacokinetic property : CHEM wherein R, R1, R2, R3, R4 and Q are defined as described in the specification.