STRUCTURAL GENE OF PNEUMOCOCICA PROTEIN.

摘要

A PURIFIED PNEUMOCOCAL SURFACE PROTEIN (PSPA) INCLUDES A TRUNCATED FORM OF THE PSPA PROTEIN THAT IS IMMUNOPROTECTIVE AND CONTAINS THE PSPA PROTECTIVE EPITOPES. THE PSPA PROTEIN IS SOLUBLE IN A PHYSIOLOGICAL SOLUTION AND LACKS AT LEAST THE CELL MEMBRANE ANCHOR REGION OF ALL PROTEIN. PROTEIN IS FORMED BY INSERTION-DUPLICATION OF MUTAGENESIS OF S.PNEUMONIAE WITH THE GENE PSPA AND THE EXPRESSION OF PROTEIN TRUNCATED IN THE GROWTH.