3-(CONDENSED RING-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES AND 3-(NITROGEN ATOM-SUBSTITUTED) PHENYL-5BETA-AMIDOMETHYLOXAZOLIDIN-2-ONES

摘要

PROBLEM TO BE SOLVED: To obtain a new 3-(condensed ring-substituted) phenyl-5- amidomethyloxazolidinone useful as an antimicrobial agent. SOLUTION: This 3-(condensed ring-substituted) phenyl-5-(amidomethyl) oxazolidin-2-one is shown by formula I [R1 is H, an alkyl, a cycloalkyl, an alkenyl, phenyl, pyridyl, etc.; either R2 or R4 is H and the other and R3 form a group of formula II (n3 and n4 are each 0-3; n7 and n8 are each 0 or 1; R10-1 and R10-2 are each H, an alkyl, etc.; R10-3 and R10-4 are each as shown for R10-1 and R10-2 ), etc.; either R5 or R6 is H and the other is H, an alkyl, etc.], and its pharmaceutically permissible salt such as 3-(1'-oxo-2'-methyl-5'- indanyl)-5-(acetamidomethyl)oxazolidin-2-one. The compound of formula I is prepared by obtaining a compound of formula IV through three processes from a compound of formula III, then forming a compound of formula V, reducing the compound with H2 and further acylating the resulting compound.