DRUG PREPARATION HAVING IMPROVED IN VIVO TOLERANCE

摘要

PROBLEM TO BE SOLVED: To obtain the subject preparation useful for the treatment of malignant tumor, inflammatory disease and autoimmune disease by modifying a drug preparation, thereby improving the in vivo tolerance of an active compound in therapeutic use and, in some case, increasing the drug effect. SOLUTION: The objective drug preparation is prepared by including a glycosyl-Y-[-C(=Y)-X]p -W(R)n -X-C(=Y)-active compound (glycosyl is an enzymatically cleavable polysaccharide, etc.; W is an aromatic group, etc.; R is H, methyl, etc.; (p) is 0 or 1; (n) is an integer; X and Y are each O, NH, etc.; the active compound is a biologically active compound linked through hydroxyl group, etc., especially anthracycline, preferably doxorubicin, etoposide, vindesine, vinblastine, etc.), a sugar and/or a sugar alcohol (glucose, mannose, fructose, etc.), a pharmacologically permissible carrier and optionally a bivalent ion (Ca, Mg, Fe, etc.).