NOVEL DERIVATIVES OF 2-CYAN-3-HYDROXYPROPEN AMIDES, METHOD OF OBTAINING THEM, THEIR APPLICATIONS AS DRUGS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The invention relates to the products IMAGE in which A, B and E represent =CH- or N with A or B or E = N, R represents cycloalkyl, alkenyl or alkynyl (/= C6), R1 represents H or (C1-3)alkyl, R2 and R3 represent H, Hal, CN, NO2, (C1-6)alkyl, -cycloalkyl, -alkoxy or -alkylthio, -(CH2)m-CX3, -O-(CH2)m-CX3, -S-(CH2) m-CX3, -O-(CX2)m-CX3 or -S-(CX2)m-CX3, m being 0 to 3 and X being halogen, or -COR4, R4 being H, alkyl or cycloalkyl (/= C3) or R2 and R3 together form -O-CH2-O-, as well as to their tautomeric forms and to their salts with bases. The products (I) have advantageous anti-inflammatory properties.