ATG-1100 (AIF-1-Gamma), a splice variant of AIF-1/RC-9

摘要

ATG-1100 (AIF-1-gamma) polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ATG-1100 (AIF-1-gamma) polypeptides and polynucleotides in the design of protocols for the treatment of atherosclerosis, CHF, restenosis, hypertension, fibrotic vasculopathies (diabetes, SLE, AS), cerebrovascular events (e.g. stroke), hematopoietic disorders, ARDS, cancer (particularly leukemias), autoimmune diseases (e.g. HIV-infection and AIDS), fibroproliferative disorders (e.g. psoriasis), inflammatory disease (e.g. RA, Crohn's, IBS), glomerulopathies and disease states, both cardiovascular and non-cardiovascular, which are characterized by aberrant fibroproliferative/inflammatory responses, among others, and diagnostic assays for such conditions.