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Compositions and methods for treatment of infection caused by Haemophilus influenzae and Streptococcus pneumoniae
Compositions and methods for treatment of infection caused by Haemophilus influenzae and Streptococcus pneumoniae
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机译:用于治疗由流感嗜血杆菌和肺炎链球菌引起的感染的组合物和方法
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摘要
The invention relates to a method of identifying a compound capable of disrupting the addition of choline onto a bacterial cell surface component comprising incubating a sample of bacteria in a solution containing choline in the presence or absence of a test compound, and assessing the effect of the test compound on the addition of choline onto the bacterial cell surface component, wherein a lower level of choline on the cell surface component in the presence of the test compound, compared with the level of choline on the cell surface component in the absence of the test compound, is an indication that the test compound inhibits the addition of choline onto the cell surface component.
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