Polycyclic derivatives of phthalazine, use of polycyclic derivatives of phthalazine and medicine

摘要

"POLYCYCLICAL DERIVATIVES OF FTALAZINA, USE OF POLYCYCLIC DERIVATIVES OF PHALAZINE AND MEDICINE". The present invention relates to new derivatives of polycyclic phthalazines, especially 2 - substituted mature phthalazines (10, 12, 15, 16 - tetrahydroxy - 8 - methoxy - 11 - methyl - 1, 9, 14 - trioxo - 1, 2, 6, 7, 9, 14 - hexahydronaphtacene - [1,2-g] - phthalazine) of formula (I) and its use. The bonds according to the present invention are active against gram-positive bacteria, particularly against multiresistant staphylococci (MRSA) as well as resistant to glycopeptides, such as enterococci, and are therefore suitable for the manufacture of antibacterial drugs. In formula (I) R ^ 1 ^ is carboxyalkyl or carboxyaryl as well as one of its salts, starches or esters and R ^ 2 ^ and R ^ 3 ^ are H or acyl (for example CO-Alkyl, COO-alkyl), being R ^ 1 ^ is different from substituted carboxyphenyl, when R ^ 3 ^ is C ~ 1-8 ~ alkanoyl.