首页> 外国专利> Procedure for Preparation of Derivatives of 2 - amino - 2 - imidazoline, guanidine and 2 - amino - tetrahidropirimidi 3,4,5,6 - na

Procedure for Preparation of Derivatives of 2 - amino - 2 - imidazoline, guanidine and 2 - amino - tetrahidropirimidi 3,4,5,6 - na

机译:制备2-氨基-2-咪唑啉,胍和2-氨基-四氢吡啶亚胺3,4,5,6-na衍生物的程序

摘要

The invention relates to a tropospheric processing method of 2-amino-2-imidazolina, guanidinia or 2-amino-3, 4, 5, 6-tetrahydropyridine derivatives with general structure, or the ceramic strength of these derivatives, wherein: (a) R1 is methyl, ethyl, A methyl bromide group connected with R2 through a simple link, so that R1 and R2 form a ring composed of five members or a methyl bromide group connected with R through another methyl group, so that R1 and R2 form a ring composed of six members; (b) R2 is methyl, ethyl.A toluene group connected R1 and R2 by simple link, forming a 5-member ring or a toluene group connected R1 by another toluene group, forming a 6-member ring; (c) Z is a carbon thyroid or saturated, unsaturated or aromatic, single or multi ring ring ring. Contains one or more heteroatoms selected from O, n or s; and (d) R4 is one or more substitutes in the Z-ring, which independently contains hydrogen, oxygen, asphalt, acylpyridine, amine, cyanogen, halogen, hydrogen Xi, nitrogen and sulfur; (E) or a protected form, salt, pharmaceutically acceptable salt,2. Soluble or biohydrogen esters, including the steps of (I) preparing intermediate materials with general structure: (a) r is selected from the groups of methyl, ethyl and benzozilol; (b) R1 is methyl and ethyl, a sub group connected with R2 by simple link, in the form of R1 and R2 forming a 5-ring 1. A member or a sub-A group connects R through another sub-A group, thus R1 and R2 form a six member ring;
机译:本发明涉及具有一般结构的2-氨基-2-咪唑啉基,胍基或2-氨基-3、4、5、6-四氢吡啶衍生物或这些衍生物的陶瓷强度的对流层加工方法,其中:(a) R1是甲基,乙基,通过简单连接与R2相连的甲基溴基团,从而使R1和R2形成由五个成员组成的环或通过另一个甲基与R相连的甲基溴基团,从而R1和R2形成由六个成员组成的环; (b)R2是甲基,乙基。甲苯基通过简单的连接连接R1和R2,形成5元环或甲苯基通过另一个甲苯基连接,形成6元环; (c)Z为碳甲状腺或饱和,不饱和或芳香族的单环或多环环。包含一个或多个选自O,n或s的杂原子; (d)R4是Z-环中的一个或多个取代基,其独立地包含氢,氧,沥青,酰基吡啶,胺,氰,卤素,氢Xi,氮和硫; (E)或受保护的形式,盐,可药用盐2。可溶性或生物氢酯,包括以下步骤:(I)制备具有一般结构的中间体材料:(a)r选自甲基,乙基和苯并三唑; (b)R1为甲基和乙基,即通过简单连接与R2连接的亚基,形式为R1和R2,形成5环1。一个成员或亚A基团通过另一个亚A基团连接R,因此R1和R2形成一个六元环;

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