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Procedure for Preparation of Derivatives of 2 - amino - 2 - imidazoline, guanidine and 2 - amino - tetrahidropirimidi 3,4,5,6 - na
Procedure for Preparation of Derivatives of 2 - amino - 2 - imidazoline, guanidine and 2 - amino - tetrahidropirimidi 3,4,5,6 - na
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机译:制备2-氨基-2-咪唑啉,胍和2-氨基-四氢吡啶亚胺3,4,5,6-na衍生物的程序
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摘要
The invention relates to a tropospheric processing method of 2-amino-2-imidazolina, guanidinia or 2-amino-3, 4, 5, 6-tetrahydropyridine derivatives with general structure, or the ceramic strength of these derivatives, wherein: (a) R1 is methyl, ethyl, A methyl bromide group connected with R2 through a simple link, so that R1 and R2 form a ring composed of five members or a methyl bromide group connected with R through another methyl group, so that R1 and R2 form a ring composed of six members; (b) R2 is methyl, ethyl.A toluene group connected R1 and R2 by simple link, forming a 5-member ring or a toluene group connected R1 by another toluene group, forming a 6-member ring; (c) Z is a carbon thyroid or saturated, unsaturated or aromatic, single or multi ring ring ring. Contains one or more heteroatoms selected from O, n or s; and (d) R4 is one or more substitutes in the Z-ring, which independently contains hydrogen, oxygen, asphalt, acylpyridine, amine, cyanogen, halogen, hydrogen Xi, nitrogen and sulfur; (E) or a protected form, salt, pharmaceutically acceptable salt,2. Soluble or biohydrogen esters, including the steps of (I) preparing intermediate materials with general structure: (a) r is selected from the groups of methyl, ethyl and benzozilol; (b) R1 is methyl and ethyl, a sub group connected with R2 by simple link, in the form of R1 and R2 forming a 5-ring 1. A member or a sub-A group connects R through another sub-A group, thus R1 and R2 form a six member ring;
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