New 18-fluoro-labeled cytosine derivatives, useful as tracers for monitoring activity of transferred cytosine deaminase genes in gene therapy of tumors

摘要

18-Fluorine-labeled cytosine derivatives (I) are new. 18-Fluorine-labeled cytosine derivatives of formula (I) are new. R1, R2 = H or F, or R1 is H or CH3 and R2 is fluoromethyl, 2-fluoroethyl or F; R3 = H, F, Cl, Br, CH3or fluoromethyl; R4 = H or CH3, and the molecule must contain at least one 18-fluoro substituent. An Independent claim is also included for a method for preparing N4-(18-fluoro)cytosine (Ia) and N4-(18-fluoromethyl)cytosine (Ib).