Compound, oligonucleotide analogue or a pharmaceutically acceptable salt thereof, pharmaceutical composition, and use of an oligonucleotide analog

摘要

"COMPOUND, OLIGONUCLEOTIDE ANALOG OR PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, AND USE OF AN OLIGONUCLEOTIDE ANALOG". This invention provides novel bicyclonucleoside analogs, which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogs, which have antisense or antigen activity as well as stability in vivo. The present invention relates to compounds of the following formula (1) or their pharmaceutically acceptable salts. R2 represents a hydrogen atom or a protecting group for a hydroxy group, R2 represents an azido group or an optionally protected amino group or the like, B represents a purin-9-yl group or a group 2 -oxo-1,2-dihydropyrimidin-1-yl, which are optionally substituted by substituents selected from the group 224 below (Group 244) halogen atom, alkyl group having 1-6 carbon atoms, hydroxy, mercapto group, amino group, and the like.