METHOD FOR DETECTING A METHYLATED CpG-CONTAINING NUCLEIC ACID, KIT USEFUL IN THE METHOD AND METHOD FOR DETECTING A DISEASE ASSOCIATED WITH METHYLATION OF NUCLEIC ACID

摘要

The present invention provides a method of PCR, methylation specific PCR (MSP), for rapid identification of DNA methylation patterns in a CpG-containing nucleic acid. MSP uses the PCR reaction itself to distinguish between methylated and unmethylated DNA, which adds an improved sensitivity of methylation detection.