Tetrahydropyran derivatives as antagonists of Neurokinin 1 receptor (nk-1)

摘要

Refers to a compound of formula I wherein R1 IS F, trifluoromethyl; R2 IS F, trifluoromethyl; R3 is Methyl or hydroxymethyl; R4 is Halogen, Hydroxy, alquelino c2-c4, alquinilo c2-c4, N3, nr5r6,Among others, R5 is H, c1-c4 alkyl, cycloalkyl C3 - C7, cicloalquil C3 - C7 (c1-c4 alkyl, alkyl c2-c4, among others; R6 h, c1-c4 alkyl, cycloalkyl alkyl C2 C3 - C7, C4,Among others, R5 or R6 together to form a ring heteroalifatico 4 to 7 Atoms Ring; Z is a Link, alquileno cicloalquileno C1 - C6 C3, C6, among others, N is 1 - 2, p is 1 - 2; Q is 1 - 2.Preferred compounds are CIS, trans - (2R, 3S, 4R, 8R) - 2 - [1 - (3,5-bis (trifluoromethyl) phenyl) ethoxy] - 3 - (3,4-difluorophenyl) - 4 - viniltetrahidropirano, trans, trans - (2R, 3S, 4S, 8R) - 2 - [1 - (3),5 - bis (trifluoromethyl) phenyl) ethoxy] - 3 - (3,4-difluorophenyl) - 4 - viniltetrahidropirano, 2R, 3S, 4R, 8R) - 2 - [1 - (3,5-bis (trifluoromethyl) phenyl) ethoxy] - 3 - (3,4-difluorophenyl) - 4 - carbaldehido tetrahydropyran,Among others. These compounds are antagonists of Neurokinin 1 receptor (nk-1) and are useful for the treatment of disorders of the central nervous system