Human monoclonal antibody against costimulatory Molecule ailim Signal transducing and pharmaceutical use of the same

摘要

Immunization of Transgenic Mice producing Human Antibodies, created through genetic engineering techniques.With the ailim Molecule as Antigen to obtain various human monoclonal Antibodies capable of binding to ailim and capable of Controlling a variety of Biological reactions (For exampleThe Cell Proliferation, cytokine Production, cell death, histolysis immune Induction of ADCC, etc.) associated with the costimulatory Signal Transduction mediated by ailim (the secondary).Even More,It has been discovered that the human monoclonal antibody is effective for the treatment and Preservation of various Diseases associated with costimulatory Signal Transduction mediated by AILim, and can inhibit the initiation and / or progression of these diseases.