Process for synthesizing N-(2-(R)-hydroxy-1-(S)-indanyl)-2(R)-phenylmethyl-4(S)-hydroxy-5-(1-(4-(3-pyridylmethyl)-2(S)-N -(tert-butylcarboxamido)piperazinyl)pentane amide

摘要

In the present invention there is disclosed a process for synthesizing N-(2-(R)-hydroxy-1-(S)-indanyl)-2(R)-phenylmethyl-4(S)-hydroxy-5-(1-(4-(3-pyridylmethyl)-2(S)-N'-(tert-butylcarboxamido)piperazinyl)pentane amide of the general formula J or a hydrate thereof, which process comprises the steps of: (a) reacting for at least 5 minutes in suitable solvent one equivalent of the compound of the general formula II having the structure with excess 3-pyridine carboxaldehyde in the presence of excess reducing agent, at a temperature range of between about -78 degC and about 90 degC; (b) isolating the compound J or a hydrate thereof.