Echinocandin derivatives, processes for their preparation and their use as antifungal agents

摘要

A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I): in which either RSUB1/SUB: H or CHSUB3 /SUBand RSUB2/SUB: cyclohexyl substituted by an amine, a (CHSUB2/SUB)b-C≡N radical or RSUB1 /SUBand RSUB2 /SUBtogether with the nitrogen which carries them form a ring with 3, 4 or 5 carbons optionally substituted by an amine RSUB3/SUB: hydrogen, methyl or hydroxyl RSUB4/SUB: hydrogen or hydroxyl R: represents a linear, branched or cyclic chain T: hydrogen, methyl, CHSUB2/SUBCONHSUB2/SUB, CHSUB2/SUBC≡N, a (CHSUB2/SUB)SUB2/SUBNHSUB2 /SUBor (CHSUB2/SUB)SUB2/SUBNalkSUP+/SUPXSUP-/SUP radical, X halogen and alk alkyl Y: hydrogen, hydroxyl, halogen or OSOSUB3/SUBH, W: H or OH, Z: H, CHSUB3/SUB. The compounds of formula (I) have antifungal properties.