N3 alkylated benzimidazole derivatives as inhibitors of MEK (N3 alkylated benzimidazole derivatives as MEK inhibitors

摘要

Compounds of formula I and pharmaceutically acceptable salts and prodrugs thereof are disclosed, wherein W, R1, R2, R7, R8, R9 and R10 are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed is a method of using such compounds in the treatment of hyperproliferative diseases in mammals, and pharmaceutical compositions containing such compounds.