COMPOUNDS SHOWING ACTIVITY WITH RESPECT TO CALCIUM RECEPTORS (VERSIONS), PHARMACEUTICAL COMPOSITION AND METHODS OF TREATMENT (VERSIONS)

摘要

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (I) or (II) taken among the mentioned below group showing activity with respect to calcium receptor, pharmaceutical composition and methods of treatment of diseases caused by anomalous and mineral homeostasis, hyperparathyroidism, hypercalcemia, malignant tumor, osteoporosis, hypertension and renal osteodystrophy. In compounds of the formula (I) or (II) Ar₃, Ar₄, Ar₅, respectively, are taken among possibly substituted phenyl or naphthyl; Ar₆ is taken among phenyl substituted with different substitutes under condition that at least one substitute means OCH₂C(O)OC₂H₅. Values of other radicals are given in the invention claim. Also, invention relates to group of compounds taking among the following ones: 20Y (N-(2-chlorophenylpropyl)-1-(3-(2,2,2-trifluoroethoxy)phenyl)ethylamine); 21M ((R)-N-(3-(3-trifluoromethyl)propyl)-1-(3-methoxyphenyl)ethylamine); 21S ((R)-N-(3-(2-chlorophenyl)propyl)-1-(3-propoxyphenyl)ethyl-amine); 21T ((R)-N-(3-(2-chlorophenyl)propyl-1-(3-isopropoxyphenyl)-ethylamine; 21U ((R)-N-(3-(2-chlorophenyl)propyl)-1-(isobutoxy-phenyl)ethylamine; 21Y ((R, R)-N-(4-(3-trifluoromethyl)phenyl)-2- -butyl)-1-(3-methoxyphenyl)ethylamine; 22J ((R)-N-(3-(3-trifluoro-methyl)phenyl)propyl)-1-(1-naphthyl)ethylamine; 23A ((R)-N-(4-(3-trifluoromethoxy)phenyl)-2-butyl-1-(3-methoxyphenyl)ethylamine; 23E ((R)-N-((3-(trifluoromethoxy)phenyl)methyl)-1-(1-naphthyl)ethylamine; 23B (N-((3-methyl-4-methoxyphenyl)methyl)-1-(2-trifluoromethyl)-phenyl)ethylamine; 24J ((R)-N-(3-(3-trifluoromethoxy)phenyl)propyl)-1-(1-naphthyl)ethylamine; 24M ((R)-N-(3-(3,5-difluorophenyl)propyl)-1-(3-methoxyphenyl)ethylamine; 24V (N-((3-methyl-4-methoxy-phenyl)methyl)-1-(3-ethylacetoxy)phenyl)ethylamine; 24X ((R)-N-((3-bromo-4-methoxyphenyl)methyl)-1-(1-naphthyl)ethylamine; 24Y ((R)-N-((3-chloro-4-ethoxyphenyl)methyl)-1-(1-naphthyl)ethylamine; 25C ((S, R)-N-(4-(3-trifluoromethyl)phenyl)-2-butyl)-1-(1-naphthyl)- -ethylamine; 25D ((R,R)-N-(4-(3-trifluoromethyl)phenyl)-2-butyl-1-(1-naphthyl)ethylamine and 25E ((R)-N-(3-phenylprop-2-ene-1-yl)-1-(3-methoxyphenyl)ethylamine; or their pharmaceutically acceptable salt or complex. EFFECT: valuable medicinal properties of compounds, improved method of treatment. 32 cl, 3 tbl, 1 dwg, 163 fig, 18 ex