PHARMACEUTICAL COMPOSITION SHOWING ACTIVITY WITH RESPECT TO CALCIUM RECEPTOR, METHOD OF PATIENT TREATMENT, METHOD OF ANALYSIS OF COMPOUND EXHIBITING EFFECT ON ACTIVITY OF INORGANIC ION RECEPTOR, RECEPTOR-ENCODING NUCLEIC ACID, CALCIUM RECEPTOR

摘要

FIELD: medicine. SUBSTANCE: invention relates to preparations and methods of treatment and analysis associated with calcium receptors and other inorganic ions. Preferably molecule is able to interact as selective agonist or antagonist on Ca²⁺-receptors of a single or more (but not all) cells. These cells are taken among the group consisting of parathyroid cells, osseous osteclasts, periglomerular renal cells, proximal tubular renal cells, peripheral tubular renal cells, thick ascending branch Henle's loop cells and/or duct collecting loop cells, epidermal keratinocytes, parafollicular thyroid cells (C-cells), intestinal cells, placental trophoblasts, atrium cells, cells producing gastrin and glucagon, renal mesangial cells and breast cells. EFFECT: broadened arsenal of agents inhibiting activity of extra-cellular calcium ions in different pathological states. 56 cl, 47 dwg